Grape Seed Extract
Also known as: GSE, proanthocyanidins, OPC, vitis vinifera
Recommended Dosage
100–300 mg
Grape seed extract is rich in oligomeric proanthocyanidins (OPCs) that exhibit potent antioxidant activity and support vascular integrity by strengthening collagen cross-links in blood vessel walls. Meta-analyses demonstrate significant reductions in systolic blood pressure and heart rate, with additional evidence for reducing leg swelling (chronic venous insufficiency) and improving endothelial function. OPCs also enhance vitamin C activity and protect against UV-induced skin damage.
TL;DR: Rich source of proanthocyanidins (OPCs) with strong antioxidant activity. Evidence for blood pressure reduction, skin protection, and vascular health. Well-tolerated with few side effects.
Quick Facts
Evidence
Grade B
Studies
2
Interactions
2
Forms
1
Evidence Rating: Grade B — Moderate Evidence
Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.
Interaction Warnings
Proanthocyanidins may inhibit platelet aggregation — use caution with anticoagulants.
Additive blood pressure lowering effect.
Important Notes
- High in proanthocyanidins — different from grape seed oil
- Well-tolerated at standard doses
- Standardized to 95% proanthocyanidins for best results
Clinical Evidence (2 studies)
Grape seed extract and blood pressure: meta-analysis
Zhang H et al. (2016) — Medicine
Grape seed extract significantly reduced systolic blood pressure by 6.08 mmHg in metabolic syndrome and pre-hypertensive subjects
View on PubMedProanthocyanidins for skin photoprotection
Yamakoshi J et al. (2004) — Phytother Res
GSE reduced UV-induced pigmentation and improved skin elasticity over 6 months
View on PubMedAlternatives to Consider
These supplements target similar goals and may be worth considering alongside or instead of Grape Seed Extract.
Pycnogenol
Grade BPatented French maritime pine bark extract with 400+ published studies. Evidence for cognitive function, cardiovascular health, and skin aging. Contains procyanidins similar to grape seed extract.
Vitamin E
Grade BFat-soluble antioxidant important for cell membrane protection, immune function, and skin health. Moderate doses (200-400 IU) appear safe and beneficial. High doses (>400 IU) linked to increased mortality risk in meta-analyses. Choose mixed tocopherols and natural forms.
CoQ10 (Ubiquinol)
Grade ACritical for mitochondrial energy production. Q-SYMBIO trial showed 43% cardiovascular mortality reduction in heart failure. Depleted by statins.
Related Supplements
Pycnogenol
Grade B — Moderate EvidencePatented French maritime pine bark extract with 400+ published studies. Evidence for cognitive function, cardiovascular health, and skin aging. Contains procyanidins similar to grape seed extract.
Vitamin E
Grade B — Moderate EvidenceFat-soluble antioxidant important for cell membrane protection, immune function, and skin health. Moderate doses (200-400 IU) appear safe and beneficial. High doses (>400 IU) linked to increased mortality risk in meta-analyses. Choose mixed tocopherols and natural forms.
CoQ10 (Ubiquinol)
Grade A — Strong EvidenceCritical for mitochondrial energy production. Q-SYMBIO trial showed 43% cardiovascular mortality reduction in heart failure. Depleted by statins.
Vitamin C
Grade A — Strong EvidenceEssential antioxidant vitamin. Supports immune function, collagen synthesis, and antioxidant defense. 50% infection reduction in athletes.
🧪 Get Your Personalized Stack
See how Grape Seed Extract fits with your goals and current supplements — AI-powered, evidence-graded recommendations.
⚕️ Important Disclaimer
This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.
DoseGrade does not sell supplements and has no affiliate relationships with supplement manufacturers.