Lysine
Also known as: l-lysine, lysine hydrochloride
Recommended Dosage
500–3000 mg
L-Lysine is an essential amino acid that competes with arginine for absorption, which underlies its primary clinical application: reducing herpes simplex virus (HSV) outbreaks by limiting the arginine that HSV requires for replication. Clinical trials show reduced frequency and severity of cold sore recurrences at doses of 1-3g/day. Lysine is also critical for collagen synthesis, calcium absorption, and carnitine production, making it relevant for wound healing and connective tissue health.
TL;DR: Essential amino acid best known for cold sore (herpes simplex) prevention. Also evidence for anxiety reduction when combined with arginine. Enhances calcium absorption. Vegans are at higher risk of deficiency.
Quick Facts
Evidence
Grade B
Studies
2
Interactions
1
Forms
1
Evidence Rating: Grade B — Moderate Evidence
Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.
Interaction Warnings
Lysine increases calcium absorption — beneficial for bone health, but avoid excess calcium intake.
Important Notes
- Most effective for cold sore prevention when combined with avoiding high-arginine foods (nuts, chocolate)
- Vegans may be deficient as lysine is limiting in grains
- Essential amino acid — body cannot produce it
Clinical Evidence (2 studies)
Lysine for recurrent herpes simplex prophylaxis
Griffith RS et al. (1987) — Dermatologica
L-lysine 1g 3x/day significantly reduced recurrence, severity, and healing time of cold sores
View on PubMedL-lysine and L-arginine on stress-induced anxiety
Smriga M et al. (2007) — Biomed Res
L-lysine + L-arginine combination reduced cortisol response and trait anxiety in healthy subjects under stress
View on PubMedAlternatives to Consider
These supplements target similar goals and may be worth considering alongside or instead of Lysine.
Reishi
Grade BCalming medicinal mushroom with immune-modulating and cancer-fatigue benefits. Best taken evening for sleep support.
Pantothenic Acid (Vitamin B5)
Grade BEssential for CoA synthesis (energy metabolism, fat breakdown, hormone production). Deficiency rare but supplement shows promise for acne and stress-related fatigue.
Black Seed Oil
Grade BWidely studied traditional remedy with strong anti-inflammatory properties from thymoquinone. Evidence for metabolic health, immune modulation, and gut health. Oil form preferred for absorption.
Related Supplements
Reishi
Grade B — Moderate EvidenceCalming medicinal mushroom with immune-modulating and cancer-fatigue benefits. Best taken evening for sleep support.
Pantothenic Acid (Vitamin B5)
Grade B — Moderate EvidenceEssential for CoA synthesis (energy metabolism, fat breakdown, hormone production). Deficiency rare but supplement shows promise for acne and stress-related fatigue.
Black Seed Oil
Grade B — Moderate EvidenceWidely studied traditional remedy with strong anti-inflammatory properties from thymoquinone. Evidence for metabolic health, immune modulation, and gut health. Oil form preferred for absorption.
Zinc
Grade A — Strong EvidenceEssential mineral for immune function, wound healing, and testosterone production. Lozenges reduce cold duration by ~33%.
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⚕️ Important Disclaimer
This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.
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