Black Seed Oil
Also known as: nigella sativa, black cumin seed oil, kalonji, thymoquinone
Recommended Dosage
1000–3000 mg
Black seed oil (Nigella sativa) contains thymoquinone as its primary bioactive compound, which modulates NF-κB, AMPK, and multiple inflammatory pathways. Clinical trials demonstrate benefits for blood sugar regulation, blood pressure reduction, lipid profiles, and immune modulation. It has one of the broadest evidence bases of any traditional remedy, with over 1,000 published studies spanning metabolic, immune, and anti-inflammatory applications.
TL;DR: Widely studied traditional remedy with strong anti-inflammatory properties from thymoquinone. Evidence for metabolic health, immune modulation, and gut health. Oil form preferred for absorption.
Quick Facts
Evidence
Grade B
Studies
2
Interactions
2
Forms
1
Evidence Rating: Grade B — Moderate Evidence
Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.
Interaction Warnings
May have antiplatelet effects — use caution with warfarin or aspirin.
May lower blood sugar — monitor glucose closely.
Important Notes
- Start low (1g) to assess tolerance
- Oil form has better bioavailability than seed powder
- Avoid in pregnancy at therapeutic doses
Clinical Evidence (2 studies)
Nigella sativa: a comprehensive review of clinical trials
Tavakkoli A et al. (2017) — Phytother Res
Thymoquinone demonstrated anti-inflammatory, antioxidant, and immunomodulatory effects across 50+ clinical trials
View on PubMedNigella sativa supplementation on metabolic profiles
Daryabeygi-Khotbehsara R et al. (2017) — Complement Ther Med
Black seed oil supplementation significantly reduced fasting blood glucose, total cholesterol, LDL, and triglycerides
View on PubMedAlternatives to Consider
These supplements target similar goals and may be worth considering alongside or instead of Black Seed Oil.
Ginger
Grade AExcellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.
Beta-Glucan
Grade BDual-purpose supplement: yeast-derived for immune support (250mg), oat-derived for cholesterol (3g). Both well-supported by RCTs.
Spirulina
Grade BNutrient-dense cyanobacterium with strong evidence for immune support, lipid improvement, and antioxidant protection. Complete protein source. Quality sourcing is critical to avoid contamination.
Related Supplements
Sea Moss
Grade C — PreliminaryMineral-rich seaweed popular for its 92-mineral profile. Prebiotic fiber supports gut health. Limited clinical trial evidence despite popularity — most claims extrapolated from nutrient analysis. Iodine content requires caution.
Omega-7 (Sea Buckthorn Oil)
Grade C — PreliminaryRich source of palmitoleic acid (omega-7), a fatty acid that supports mucosal membrane health throughout the body. Emerging evidence for skin, cardiovascular, and GI benefits. Less studied than omega-3 but shows promise for dry eyes, dry mouth, and mucosal support.
Ginger
Grade A — Strong EvidenceExcellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.
Beta-Glucan
Grade B — Moderate EvidenceDual-purpose supplement: yeast-derived for immune support (250mg), oat-derived for cholesterol (3g). Both well-supported by RCTs.
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⚕️ Important Disclaimer
This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.
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