NR (Nicotinamide Riboside)

Also known as: Niagen, nicotinamide riboside, NR

Grade B — Moderate EvidenceNAD+ precursorlongevity
300–1000 mgMorning with food

Nicotinamide Riboside (NR) is a form of vitamin B3 that serves as a precursor to NAD+, the critical coenzyme involved in cellular energy metabolism, DNA repair, and sirtuin activation. Clinical trials confirm that NR supplementation (300-1000mg/day) reliably increases NAD+ levels in humans. While animal studies show promising anti-aging effects, human longevity data is still emerging. NR is generally better tolerated than niacin, without the flushing side effect.

TL;DR: NAD+ precursor with strong human RCT evidence for NAD+ elevation. Unique cardiovascular benefits: reduced arterial stiffness and blood pressure.

🧬Longevity⚡Energy❤️Heart Health
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade B

Studies

3

Interactions

1

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

ChemotherapyModerate

NAD+ boosting may theoretically support cancer cell survival; consult oncologist

Important Notes

  • Niagen (Chromadex) is most clinically studied form
  • Headache, flushing, nausea uncommon at higher doses
  • Often combined with TMG/resveratrol

Clinical Evidence (3 studies)

NR robustly elevated human blood NAD+

Trammell SAJ et al. (2016) — Nat Commun

First human pharmacokinetics: dose-dependent NAD+ elevation

View on PubMed

NR reduced aortic stiffness and blood pressure

Martens CR et al. (2018) — Nat Commun

1g/day for 6 weeks reduced aortic stiffness and BP in middle-aged adults

View on PubMed

NR raised NAD+ in skeletal muscle

Dollerup OL et al. (2018) — Nat Commun

1g/day for 12 weeks raised NAD+ in skeletal muscle; no adverse effects

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of NR (Nicotinamide Riboside).

Taurine

Grade B

Conditionally essential amino acid. Landmark 2023 Science paper showed it extends healthy lifespan in multiple species.

🧬 Longevity❤️ Heart Health⚡ Energy

NMN (Nicotinamide Mononucleotide)

Grade B

NAD+ precursor with multiple human RCTs showing elevated blood NAD+ and improved physical performance. Exciting longevity candidate.

🧬 Longevity⚡ Energy

Resveratrol

Grade B

SIRT1 activator commonly combined with NMN/NR. Human evidence for metabolic improvement and cognitive support. Lipid-soluble — take with fat.

🧬 Longevity❤️ Heart Health

Related Supplements

Taurine

Grade B — Moderate Evidence

Conditionally essential amino acid. Landmark 2023 Science paper showed it extends healthy lifespan in multiple species.

CoQ10 (Ubiquinol)

Grade A — Strong Evidence

Critical for mitochondrial energy production. Q-SYMBIO trial showed 43% cardiovascular mortality reduction in heart failure. Depleted by statins.

NMN (Nicotinamide Mononucleotide)

Grade B — Moderate Evidence

NAD+ precursor with multiple human RCTs showing elevated blood NAD+ and improved physical performance. Exciting longevity candidate.

Spirulina

Grade B — Moderate Evidence

Nutrient-dense cyanobacterium with strong evidence for immune support, lipid improvement, and antioxidant protection. Complete protein source. Quality sourcing is critical to avoid contamination.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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