PEA (Palmitoylethanolamide)

Also known as: palmitoylethanolamide, pea, palmidrol

Grade B — Moderate Evidenceendocannabinoidanti-inflammatorymood
300–1200 mgWith food; split into 2-3 doses for higher amounts

Endogenous fatty acid amide that modulates pain and inflammation via the endocannabinoid system (PPAR-alpha). Strong evidence for chronic pain relief. Exceptionally safe with no known drug interactions of concern. Micronized forms preferred.

😊Mood🧘Stress & Anxiety
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade B

Studies

1

Interactions

1

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

NSAIDsLow

PEA may complement NSAID effects — generally considered synergistic rather than problematic.

Important Notes

  • Endogenous compound — body naturally produces PEA
  • Micronized or ultra-micronized forms have better absorption
  • Very safe profile — no serious adverse events reported in clinical trials
  • Works via PPAR-alpha receptor, not directly on cannabinoid receptors

Clinical Evidence (1 study)

Palmitoylethanolamide for pain: a meta-analysis and review of clinical evidence

Lang-Illievich K et al. (2023) — J Clin Med

PEA significantly reduced chronic pain intensity across multiple conditions with excellent tolerability

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of PEA (Palmitoylethanolamide).

Myo-Inositol

Grade B

Naturally occurring sugar alcohol with strong evidence for PCOS, panic disorder, and OCD. Gentle anxiolytic. Very safe at standard doses.

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Tongkat Ali

Grade C

Southeast Asian herb with emerging evidence for cortisol reduction and hormonal support.

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Saffron

Grade A

Potent natural antidepressant with multiple RCTs showing comparable efficacy to fluoxetine at just 30mg/day. Also supports eye health.

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Related Supplements

Tongkat Ali

Grade C — Preliminary

Southeast Asian herb with emerging evidence for cortisol reduction and hormonal support.

Myo-Inositol

Grade B — Moderate Evidence

Naturally occurring sugar alcohol with strong evidence for PCOS, panic disorder, and OCD. Gentle anxiolytic. Very safe at standard doses.

Magnesium Glycinate

Grade A — Strong Evidence

Highly bioavailable form of magnesium. Strong evidence for sleep quality, muscle relaxation, and stress reduction. Most adults are deficient.

Ashwagandha

Grade A — Strong Evidence

Ayurvedic adaptogen with strong clinical evidence for cortisol reduction (15-30%), stress relief, and exercise performance.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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