Fisetin

Also known as: 3,3',4',7-tetrahydroxyflavone

Grade C — Preliminaryflavonoidlongevity
100–500 mgWith fatty meal. For senolytic use: 500-1500mg for 2 consecutive days/month.

Fisetin is a flavonoid found in strawberries and other fruits that has emerged as one of the most potent senolytic compounds identified in preclinical research — clearing senescent "zombie" cells that accumulate with aging. The Mayo Clinic is actively conducting human trials on fisetin for age-related conditions. Beyond senolytic effects, fisetin demonstrates anti-inflammatory, neuroprotective, and anti-cancer properties in cell and animal studies, though large human trials are still needed.

TL;DR: Most potent natural senolytic compound tested. Intermittent "hit-and-run" dosing protocol (2 days/month) for clearing senescent cells.

🧬Longevity🧠Cognitive Performance
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade C

Studies

3

Interactions

2

Forms

1

Evidence Rating: Grade C — Preliminary

Limited human trials, mostly animal or in-vitro data. Promising but not yet proven in robust human studies.

Interaction Warnings

WarfarinModerate

CYP2C9 effects; monitor INR

ImmunosuppressantsLow

Potential interaction; caution

Important Notes

  • Intermittent dosing preferred for senolytic use
  • Low bioavailability (10-20%) — take with fat or use phytosome/liposomal
  • Human data still limited

Clinical Evidence (3 studies)

Fisetin most potent senolytic among 10 flavonoids

Yousefzadeh MJ et al. (2018) — EBioMedicine

Most potent senolytic tested; extends health/lifespan in mice

View on PubMed

Fisetin reduced biological aging markers in humans

Lee SJ et al. (2024) — Aging

Pilot RCT using TruAge methylation clock showed reduced aging markers

View on PubMed

Fisetin as senolytic targeting senescent adipocytes

Zhu Y et al. (2017) — Aging (Albany)

Effective against senescent adipocyte precursors

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Fisetin.

Resveratrol

Grade B

SIRT1 activator commonly combined with NMN/NR. Human evidence for metabolic improvement and cognitive support. Lipid-soluble — take with fat.

🧬 Longevity🧠 Cognitive Performance

Spermidine

Grade B

Autophagy inducer with strong epidemiological link to reduced all-cause mortality. RCT evidence for memory improvement in elderly.

🧬 Longevity🧠 Cognitive Performance

Taurine

Grade B

Conditionally essential amino acid. Landmark 2023 Science paper showed it extends healthy lifespan in multiple species.

🧬 Longevity

Related Supplements

Resveratrol

Grade B — Moderate Evidence

SIRT1 activator commonly combined with NMN/NR. Human evidence for metabolic improvement and cognitive support. Lipid-soluble — take with fat.

Spermidine

Grade B — Moderate Evidence

Autophagy inducer with strong epidemiological link to reduced all-cause mortality. RCT evidence for memory improvement in elderly.

Omega-3 Fish Oil

Grade A — Strong Evidence

Essential fatty acids with strong evidence for cardiovascular and mental health. EPA-dominant for mood; triglyceride form for absorption.

PQQ (Pyrroloquinoline Quinone)

Grade C — Preliminary

Stimulates mitochondrial biogenesis (creation of new mitochondria). Best paired with CoQ10. Still early research.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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